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I'd go with the E350. The M45 is the Nissan Stanza of luxury cars.
As much so as the GS330 is the Toyota Corolla of luxury cars.
They are all awesome and I would love to have any one of them.
The M45 is a rocket with great looks. The M35 is quick with the same good looks. I think it is the only one that you can get with a STICK. Infiniti is probably $10K cheaper than the two others as well.