yah it can be done, but ur gonna have to get custom mounts made, gonna have to reroute the rear differential to the back by customizing the underbody, gonna have to get a custom gas tank to get it out of the way, then ur looking at alot of work creating the rear wheel drive axles with assembly to fit the back end, will need really nice suspension system in order to handle all the weight on the nose of ur car and the new rear suspension, not to mention pretty much everything that comes out of the s2000, bigger fuel pump, custom air intake, etc. new custom exhaust. plus a ton of stuff i dont feel like naming cuz my head hurts, but id only suggest diong this if ur planning on making a show car, not a daily driver or even a drag car, ur better off just getting a strong block and turbocharging the sh!t out of it, and u'll save urself many thousands of dollars.

this guy built a crx with a crv+awd+turbo setup so nethign can be done
http://public.fotki.com/morgie/qsr/crx_gsr_awd_turbo/