glock dont make a .454 nor would your wife want to shoot it

you could look at a 44 mag ... with a little practice she could shoot it but glock no make 44 mag and it is on the larger side for pistols

if you're looking at glock look at like a G22 or G21 those are the .40 and .45 full size models

edit:
failed to mention 44 mag is also revolver based, don't know if that would make a difference for you