So, uh... what seems to be the hypothetical problem people?

The rules of making power change with boost, and they also change with your method of boost. SC? Nitrous? Fine, stay with low overlap, high lift and high duration. Turbo? Overlap in the low mid-range is your friend, it helps get that turbo spooling several hundred RPM faster, especially given the fact that a turbo will flow enough air to maintain a given PSI in the intake manifold, what happens if some skips the cylinder while both valves are open? It hits the turbine and keeps it spooled, so it will still maintain the PSI, and wow, you don't drop out of boost... What's the downside again?

As far as the CR issue: cylinder pressures and the right amount of fuel is what makes power, get cylinder pressures too high for the amount of usuable fuel and things burn and melt. The thing to keep in mind, however, is that the gains of higher PSI usually outweigh the benefits of having a high static CR, but you can make just about anything work.