Switching to synthetic oil in a high-mileage motor is not recommended. Syth flows *so* well and is *so* clean that it will remove all the old oil sludge that's filling all the little holes in the motor. Often the owner will develop "new" leaks that were previously patched with sludge.
However if you have a low miles motor, I'd say go for it. W/in a given viscosity you will make a few more horses running synth. Nothing really noticeable, IMHO.
I ran synthetic in my turbo car because of the potential for extreme heat that could be seen if I didn't use a turbo timer. I recommend synth for turbo cars-- especially oil-cooled turbos.
Because synth doesn't break down like natural oil, you can technically run longer between oil changes.
I was really surprised when I changed my oil for the first time w/ synth. It comes out looking exactly like the way it went in!
-scott