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if you're not going to use it in windows, you can format it with the mac filesystem (HFS+ or whatever).
or you can use NTFS, but the mac can only read to a disk that's NTFS unless you install a separate driver or whatever it's called. i think i used MacFUSE at home.
i haven't had a problem, but honestly, i haven't used it that much. i've only connected an NTFS drive to my mac once, and i was able to use it like a regular drive (with macfuse installed). but i haven't even used my mac since really.