it is very possible for a 6th gen... with relatively minor work.. the motor is not much larger than the j30.
Oh, and some horsepower corrections... in the odyssey's first few years in its newer design, the motor had 200hp... in 2001 they upped it to 240hp... Only the MDX has the 260hp 3.5.
You'd also be getting a 5-speed auto if you get the 240hp odyssey motor or the 260hp MDX motor.