you can't take the back console out to put in bigger speakers through the hole
BUT i've seen alot of sol's at the NOPI Nats that had taken the back console and used fiberglass and other materials to "re-sculpt" the back console. I've seen big LCD screens with organicly flowing moldings and 10" woofers molded into it, but i'm not sure if i've seen 12's.... this of course takes fairly major $$$$$ to customize
I saw an enclosed single 10" lower profile box in the Crutchfield catalog with a built in amp that the dimensions say would mount between the seats to the rear console for about $400. Could be an option if you MUST have the BOOOOOOM.