I have 18x7.5 w/ 45 offset.
I'm dropped a little more than 2.5".
I rub a rub a little in the front using 225/40/18 and camber kit (right now my front camber is - 0.6).
No rub w/o camber kit in front, but I would have > -2 camber.
Using 215 tires would help a little.
As for rear, absolutely no rub, even after I put washers to fix the camber.