I've always been intrigued by monster swaps like this... I used to own a 240 DL Volvo... and a lot of people hated the weak, poorly built engines, and would do "monster swaps" like a 5.7L LS1 V8, or a 5.0 Cobra engine. I have pics of both... but I don't think the front end of Honda/Acuras is strong enough to support anything larger than a four. I would love to see a Supra motor in the Integra, but it would take an incredible amount of work. Plus a fantastic amount of money...
If you DO go with it, keep me updated. It would be a one-of-a-kind. I would take some measurements first, and post this under Engine Tech, Hybrids, or try some Supra boards. Good idea, however impossible the execution might be...