The whole "OBD1 responds better to mods than OBD2" thing is a complete overstatement. The only sort of tuning restriction an OBD2 ECU poses is that it has a learning capability which prevents you from running advanced ignition timing.

The way it works is basically like this:

In the ECU there are stored base maps for fuel and ignition. Base timing on the distributor is set to 16 degrees BTDC. The ECU is able to advance or retard the timing on the fly. The OBD1 computers assume the distributor is always set to 16 degrees of advance and adjusts the timing by a certain number of degrees to achieve the desired value in the stored map. If you advance the timing to 18 degrees BTDC, then you will get 2 degrees more advance across the board.

OBD2 computers are able to "figure out" that the distributor has been advanced and will eventually learn to compensate for the extra advance and still give you the same timing value as what is laid out in the stored map. It doesn't happen immediately but it does eventually do its job.

One other issue with the OBD2 computers is that they're as of yet "unchippable" for the most part so if you want to get a Hondata or something along those lines you have to convert your wiring back to OBD1 because the plugs are different.