Well there are supposed to be atleast 18 in between the rca's and power wire. I would think having speaker wires with the rcas shouldn't cause a problem but i can't say for sure. My rcas and speaker wires are together and run down the center. I have a suspecsion my deck or the wiring harness right near it is causing it. When i move the deck it stops. Its starting to really get on my nerves ive had to pull the deck out too many times.