It all depends on tuning. You can expect to pay:
$500 S200B
$50 DSM Injectors
$5 Resistors
$150 Injector/Hondata Install
$60+/hr partial throttle street tuning (different than dyno)
$175+/hr dynotuning, minimum 2hrs

And thats conservative....any standalone is expensive. Tuning, unless you do it yourself, is expensive. You pay for the dyno and pay for the tuner.

Compare that to:

Cartech FMU - $200
SMC - $125(?)/AFC - $300
BTC/Map Mod - $300/$175
310's - $200
Tuning time...I dont even know how long, but it wont be nearly as accurate. Like I said...with Hondata you may pay a bit more, but for the end result, its worth it....I did it...my wallet hurts, and has a lot more hurtin to go, but Im still alive on 6PSI for 20k and 11PSI for 5+k now....Im knockin on wood though, every day