At this point in time, it's really hard to make a lightweight 2-seat car and still meet government crash standards. The only cars that come to mind are the Miata and MR2 Spyder. Honda would have to develop a new platform to keep the weight of any hypothetical future CRX at a reasonably low level, the Global Compact platform is too large. And if they did, it wouldn't really be a CRX because the CRX was always based on the Civic platform.

But if you think about it, the CRX was sort of replaced by the S2000. The del Sol was the CRX in the rest of the world, so the CRX had already become a roadster of sorts. Then the S2000 comes out as another 2-seat roadster albeit no longer Civic-based and no longer that cheap or lightweight.