.......... All the honda v6s are front wheel drive transmission. You would have to build something custom to make it rear wheel drive. v6s are not supported (after market parts, steel rods, tuning options) but the s2000 engine is. If I had a shell of a s2000 and money I would get a s2000 engine and trans do some research they have a lot of after-market support.
I am not trying to slam you if you have time, money and good fab skills anything is possible.