QX4's had headgasket/cooling and trans issues.
I'd get the newest and lowest mileage vehicle you can. High mileage isn't a BAD thing, but it doesn't mean a good thing either. is this a commuter/ personal daily use? I really like the styling of the qx4 except for the reliability thing. The Runner is fairly easy to fix and there are tons of web diy resources so you could repairs yourself.