I realize what happens as they wear, it's inevitable that the clutch packs will deteriorate and contaminate the fluid. On a Honda automatic, at least, I would expect that such a significant amount of friction material floating in the fluid wouldn't take long to clog up the mesh screens on solenoids, etc. That's if it didn't start slipping before that could even happen. Certain models, b/c of design differences, may be less susceptible to that - I'm not an expert on the subject, but I base my advice on what I've been told by Honda service technicians/engineers.

Just one recent ex. that comes to mind would be an '01 civic auto, original fluid, ~100k miles where 2nd gear began to slip. Obviously the friction material had deteriorated too much, but despite original fluid (so all that crap was still floating around) the transmission began to slip and had to be replaced. The fluid was burnt of course and the owner was told that, with the rebuilt trans. that was installed, they should stick to 30k fluid changes in order to prolong it's life.