It isn't just 4-1 or 4-2-1. A lot of pricey headers are actually 4-2-1, but they merge so fast they give the benefits of a 4-1 as well as not totally raping low end in the ass.
Don't believe the 'hondas don't gain power from bolt ons' myth.
This myth was established by people who bought a short ram intake, OBX header, and cheap fart can exhaust, and wonder why they didn't make any power.
If you buy quality components you will have power gains. Plain and simple.