These bikes come into mind:

kawasaki 500R
kawasaki Z750S
Honda 599
Suzuki SV650(non S)
Suzuki GS500
Yamaha FZ6

I've rode all of them and they are pretty comfortable and have upright seating positions. Leg room, that's a different story although they are still way more comfortable than 'crotchrockets'. These are all standards; although the 500R is usually considered a 'sportbike' and has fairings and the 04 and up GS500 have fairings that model their GSXR cousins. I had an 00 GS and I loved it.