yeap, just like these guys said!
If the fuse is blown, it'll break the power circuit to the battery. Swap it out with the same "amp" fuse and you'll be good. I'm not sure how it is on the 5th gens, but on the 6th gens the "RADIO" fuse also holds the charge for the ECU. So, what's the big deal?
The ECU is reset when power is disrupted. There's always a small electrical charge running to it, just like your radio and how it saves FM stations. When you change the fuse and the radio is fine again, be sure to let your car idle on the driveway for 5 minutes. Drive normally, no flooring it, for 15 minutes afterwards. Your ECU needs to re-learn it's fuel/air mixture again.