TSX will handle better.
In terms of speed go...Accord I4 < TSX < AV6
Looks are subjective, but IMO TSX > Accord coupe > Accord sedan (even though the refreshed Accord looks a lot better now imo).
Luxury, TSX gets the nod, but an Accord EXV6 is right up there as well.
I'd take the TSX because I like 4 doors for everyday driving, nice balance of handling, speed, luxury, looks, and of course Honda reliability.