rcurley is correct about more midbass from the larger driver. However, seanbean did say that he would be using them for highs only....

Anyway, here's my shpeal: If you 6.5" will fit without any depth problems, then by all means, go for it. However, since Honda/Acura's suck and have little to no depth for aftermarket speakers, a 5.25" driver may be easier to install, so less headache and cutting....