I replaced the speakers on my 00 GSR, I assume the interior is similar. The door panels come off pretty easy, just follow what the book sais. I replaced the rear speakers without completely remove the side panels. You have to remove the rear panel in the truck to free up the rear part of the side panel, remove the bolts the hold the panel to the body and peel it away enough to access the speakers. It's kind of a pain. I wish honda would have made the grill large enough to pull the speaker through.
Scott