Not too much when its the Comptech 4-2-1. Comptech is pretty competent when it comes to designing their products, and they were aiming for a 4-2-1 header that shys away from the classic "4-1 high end, 4-2-1 low-mid" thought.

The Comptech gives pretty good gains throughout the powerband in terms of what just a header would do for you, but this is also all relevant to your specific setup. It is definitely one of the better 4-2-1 headers on the market.

The difference between a DC 4-2-1 and DC 4-1 would be more apparent.