A lot of people keep saying the Prelude is dead forever because of the RSX, when in fact the RSX made the Integra extinct.
Personally, I feel the V6 Accord Coupe for '03 is going to be the temporary replacement for the Prelude.
If you look back into automotive history, perennial top sellers that died have come back. Celica, MR2, Z, eventually the RX, possibly Supra and 240.