I had an Accord EXR with 220,000km on it and it suddenly seized up right after I refueled while on a road trip.
I replaced the F22 with an H22A and after two years I'm looking at a rebuild because I dyno tested my engine and I was at 123whp.
Honda's don't have extraordinary reliability. They're just cars. Some cars are horrible, many are average, but none are invincible. (I know that no one said that Hondas were invincible.)