I haven't driven the MR-S but have driven many S2000's. I can't believe you are comparing these two cars. The Honda S2000 is in another class in my opinion. The only complaints that can be made about the S2000 are far and few and really only exist for the following reasons. Let me explain.
Someone might say
- not much interior room
- not much trunk space
- hard to see with top on - this increases w/hardtop (blindspots)
- firm ride
- not as comfortable to drive around town to grocery store etc.
- small powerband, needs to rev high to make its power
All of these really amount to nothing in a way. I mean you can't judge a sports car on family sedan features. The S2000 is a tribute to Honda's FI racing history and a tribute to VTEC technology and Soichiro himself. This car is Honda's true sports car. It does want to be driven hard and out-performs many others at the track. It is a race car in a reliable package. With the highest HP/L output of any other naturally aspirated 4-cylinder engine (120 HP/L), a 50/50 weight ratio, and a motorcycle like 9000 rpm redline, the S2K is a true supercar. I think that when they built the S2000 they made it perfect. Others may say that it was made better with the new one in 2004. No matter your opinion I think it is apparent that the Honda S2000 is one of the best roadsters ever built.
Toyota's are really great cars too. Toyota makes some of the most reliable cars in the world without a doubt. Then so does Honda. My pick would be the S2000 this time hands down. My first drive hitting VTEC took my breath away. I would say each drive after that, even when not driving spirited was the same. I have driven too many to count. 2000's-2004's. I worked at a Honda dealership for 2 years. I have worked on them and driven them and would recommend it to you! GOOD LUCK ON YOUR PURCHASE!
-Charlie