My vote goes to Spybot S&D.

I ran Ad-Aware on my machine like 3 or 4 times and while it did get rid of quite a bit of stuff, I still got the damn "www.bestsearch.cc" startup page when I clicked on IE. I deleted the favorite added to my favorites list "teens anal fvcking" and changed my homepage numerous times but still came back up when I clicked on IE. Last night I downloaded and ran Spybot, clicked on IE this evening and it's all gravy!