I don't have a solid yes/no, but I'm hoping that I can provide some useful info.
I recently picked up my ITR from a fellow autocrosser. The car has 225 Victoracers mounted on Millenia rims which have a same offset as stock. When using the 225's, I need to run 5mm spacers so the tires won't rub. Based on my understanding of ITR's offset at 40-42mm, I think the 45mm offset would be the way to go w/o the spacers.
However... This does not take into account the fact that your car is lowered. My ITR is still at the stock height.
Perhaps a fellow autocrosser has experience with 225's on a lowered ITR.