the biggest change for an na engine will be compression. finding the optimum compression for your engine without relying on race fuels.
normally people run up to 12.5:1 compression ratio. maybe 50psi fuel pressure and slightly larger injectors (slightly)
a general rule is the higher the compression, the higher the octane you have to use. 91-95 octane for 12.5:1 is sufficient.
also tuning the car depends on what altitude you are in.
for instance a car dynoed in colorado will dyno differently than one in florida. altitude and pressure plays some role considering the engine is relying on atmospheric pressure to 'breath' with.