teh most common signs that a car is out of alignment are:

1. one worn shoulder on a tire(s)
2. pull in one direction, pulls consistently at all speeds (this can also be caused by a tire which is known as a "radial pull")(pulls at specific speeds or only when accelerating is known as "torque steer" and is caused by your transmission)(pull when braking is also obviously a problem with your brakes)
3. cocked (off-center) steering wheel (usually a result of hitting something like a curb at a decent speed)

Misalignment does NOT cause vibration--4 obvious things to check when getting a vibration:

1. tire/wheel balance (usually causes vibration at specific speeds 50mph and up)--also check or feathering/cupping wear patterns on the tires(which can be an indication of other problems
2. out of round wheel or seperated tire, also causes vibration at specific speeds, seperated tires generally create vibration at all speeds
3. loose or worn part in frontend/susp (strut mount, TRE, Balljoint, etc.)
4. transmission problem (can occur at specific speeds, but only happens when accelerating or when maintaining speeds, does not occur when in neutral)