I'm sure some are easier than others, but sometimes its also the person. Someone scientificly inclined will do better with a bio or chem major as opposed to an economics or business major.

There are some degrees which are harder...for example, my roommate last year was majoring in civil engineering, so for his major he wasn't required to have a minor, unlike me, which I am required to have an option and a minor (option = inside business, minor = outside business).