I found personally, it doens't matter when I took it. As long as I exercised and drank GALLONS of water, it worked fine. It might be different for different people. I never took the serum, I took the tablets. I usually take it everyday for 2 months, then go off of it for 2 months, and so on.

Creatine only works if you drinks TONS of water(not liquids), and exercise daily(doesn't have to be a 3 hour workout, but a run or something).

Hope that helps a little. If you need some more info, lemme know. I was a personal trainer for 2 years.

Spike