No reason why you couldn't use a two channel. One channel to each side. You could always add another 2 channel later on and have effectivly a 4 channel. Depends on the rout, space money ect.
As far as wiring you will have wires from the amp to the crossovers (+ and -) then from the crossovers there will be two wires, one will go to the tweeters(+&-) and the other to the mid(+&-). DO NOT GET THESE MIXED UP. If you do youll probably have to buy new speakers. Double check before you power up. Most eqs don't have x-overs you may need to buy a seperate x-over the get all those inputs. Why do you need so many?