Wow... this devolved fast.
After living in Santa Cruz for 3 years, and literally seeing all that different gender and sexualities have to offer the world, and I've decided that it makes no difference two loving people do. This comes from experience of living with gay people, being friends with gay people, and just growing up.
The only time a gay person will make me feel uncomfortable is the occasion when a gay guy refuses to drop the chase on me. If I tell someone that I'm not interested, I expect them to respect it. I expect that of everybody, in fact.