All you need is colums, adjust the page type to 4.25x4.25 and insert an image, right?

you might want to use inDesign if you're gonna use vector images. but you have to do the images in illustrator and then import them as .tif
and a tip for placing images. i usually dont use the place tool. since that just link the image and you'll need to make sure your iimage is attached to the doc. i usually just copy/paste from illustrator to indesign

i suppose, but i dont think word handles vector images, itll rasterize it and itll come out crappy.

I like pagemaker.... but I haven't used it since 1995