Scientists cure cancer, but no one takes notice.
05-14-2007, 10:52 AM
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Scientists cure cancer, but no one takes notice.
05-14-2007, 11:10 AM
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http://en.wikipedia.org/wiki/Dichloroacetate
interesting, although the wiki article says:
"These results received extensive media attention, beginning with an article in New Scientist titled "Cheap, Safe Drug Kills Most Cancers".[11] Subsequently, the American Cancer Society and other medical organizations have received a large volume of public interest and questions regarding DCA.[12]"
doesn't seem like quite the conspiracy, it just doesn't have the funding of a major pharm company to get trials going on the scale that is needed.
interesting, although the wiki article says:
"These results received extensive media attention, beginning with an article in New Scientist titled "Cheap, Safe Drug Kills Most Cancers".[11] Subsequently, the American Cancer Society and other medical organizations have received a large volume of public interest and questions regarding DCA.[12]"
doesn't seem like quite the conspiracy, it just doesn't have the funding of a major pharm company to get trials going on the scale that is needed.
05-14-2007, 11:10 AM
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05-14-2007, 11:12 AM
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Originally Posted by wiki
Reports in the lay press after the 2007 University of Alberta announcement claim that dichloroacetate "has actually been used safely in humans for decades",[18] but the limited scholarly literature suggests side effects of pain, numbness and gait disturbances in some patients.[18] A clinical trial where DCA was given to patients of MELAS (a form of genetically inherited lactic acidosis) at 25 mg/kg/day was ended prematurely due to excessive peripheral nerve toxicity.[19] Dichloroacetate can also have anxiolytic or sedative effects.[20]
Animal studies suggest that the neuropathy and neurotoxicity during chronic dichloroacetate treatment may be partly due to depletion of thiamine, and thiamine supplementation in rats reduced these effects.[21] However, more recent studies in humans suggest that peripheral neuropathy is a common side effect during chronic DCA treatment, even with coadministration of oral thiamine.[22][23] An additional study reported that 50 mg/kg/day DCA treatment resulted in unsteady gait and lethargy in two patients, with symptoms occurring after one month for one patient and two months for the second. Gait disturbance and consciousness were recovered with cessation of DCA, however sensory nerve action potentials did not recover in one month.[24]
Animal studies suggest that the neuropathy and neurotoxicity during chronic dichloroacetate treatment may be partly due to depletion of thiamine, and thiamine supplementation in rats reduced these effects.[21] However, more recent studies in humans suggest that peripheral neuropathy is a common side effect during chronic DCA treatment, even with coadministration of oral thiamine.[22][23] An additional study reported that 50 mg/kg/day DCA treatment resulted in unsteady gait and lethargy in two patients, with symptoms occurring after one month for one patient and two months for the second. Gait disturbance and consciousness were recovered with cessation of DCA, however sensory nerve action potentials did not recover in one month.[24]
